Figure 2: AS-1 decreased myocardial infarct size and improved cardiac function following myocardial ischemia/reperfusion injury. | Scientific Reports

Figure 2: AS-1 decreased myocardial infarct size and improved cardiac function following myocardial ischemia/reperfusion injury.

From: TIR/BB-loop mimetic AS-1 attenuates cardiac ischemia/reperfusion injury via a caveolae and caveolin-3-dependent mechanism

Figure 2

(A) Mice were treated with AS-1 or vehicle control, DMSO by i.p. injection immediately before reperfusion (4 h) after ischemia. Hearts were harvested and infarct size was determined by TTC staining. The infarct area (white) and the area at risk (red + white) from each section were measured using an image analyzer. Ratios of risk area vs. left ventricle area (RA/LV) and infarct area vs. risk area (IA/RA) were calculated and were presented in the graph. (B) AS-1 administration improved cardiac function following myocardial I/R. AS-1 or vehicle control, DMSO were injected immediately before reperfusion after ischemia (45 min). Cardiac function was examined 24 hours after I/R by echocardiography. Ejection fraction (EF%); fractional shortening (FS%). n = 6, #P < 0.05 compare to sham; *P < 0.05 compared with indicated groups.

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