Table 3 Associations of PIGD severity with the levels of Aβ1–42 and P-tau181t in CSF in univariate and multivariate linear regression models with adjustment for potential confounders.

From: Phenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters

Variable

Univariate

Multivariate

β

P value

β

P value

β

P value

Age (years)

0.181

0.000**

0.009

0.876

0.640

0.893

Age of onset (years)

0.049

0.253

−0.032

0.923

−0.020

0.803

Sex (male/total, %)

−0.007

0.859

−0.288

0.422

0.057

0.883

Education (N, %)

−0.092

0.030*

0.022

0.945

0.342

0.311

Predominantly affected side

0.008

0.861

−0.240

0.395

0.018

0.73

MoCA (scores)

−0.231

0.000**

−0.066

0.048*

0.037

0.047*

Disease duration (years)

0.300

0.000**

0.126

0.288

0.059

0.624

Hoehn-Yahr stage (stage)

0.653

0.000**

2.130

0.000**

2.247

0.000**

Aβ1–42 in CSF (ng/ml)

−0.221

0.018*

−1.178

0.014*

—

—

P-tau181t in CSF (pg/ml)

0.224

0.000**

—

—

0.018

0.012*

  1. MoCA = Montreal Cognitive Assessment; Aβ1–42 = β amyloid (Aβ)1–42; P-tau181t = tau phosphorylated at threonine 181. *P < 0.05, **P < 0.01.
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