Table 2 Ki67 and p53 expressions in relation to clinicopathological parameters (mean ± SD).

From: Tumor Wide Horizontal Invasion Predicts Local Recurrence for Scrotal Extramammary Paget’s Disease

  

Ki67(%)b

p53

Positive expression (n,%)c

Expression scoreb,d

Delay in diagnosis (years)

<7

33.45 ± 20.18

116 (63.4%)

1.04 ± 0.31

≥7

32.96 ± 21.46

15 (65.2%)

1.18 ± 0.41

P

0.915

0.864

0.162

Tumor size (cm2)

≤25.0

34.98 ± 20.65

69 (57.5%)

1.04 ± 0.26

>25.0

31.33 ± 19.79

60 (69.8%)

1.06 ± 0.39

P

0.255

0.073

0.806

Multiple lesions

Absent

34.01 ± 20.35

114 (62.3%)

1.06 ± 0.35

Present

29.05 ± 19.85

16 (69.6%)

1.00 ± 0.00

P

0.296

0.496

0.056

Invasion level

In situ

33.80 ± 20.41

117 (63.9%)

1.04 ± 0.33

Micro-invasion

23.56 ± 20.88

7 (70.0%)

1.17 ± 0.41

Deep invasion

35.91 ± 17.72

6 (46.2%)

1.00 ± 0.00

P

0.312

0.406

0.643

Nodule formation

Absent

33.21 ± 19.95

126 (64.0%)

1.05 ± 0.33

Present

37.14 ± 28.70

4 (44.4%)

1.00 ± 0.00

P

0.732

0.295

0.836

Ulceration

Absent

32.99 ± 19.77

123 (62.8%)

1.03 ± 0.27

Present

39.40 ± 27.87

7 (70.0%)

1.33 ± 0.82

P

0.334

0.643

0.028*

Lymphovascular Invasion

Absent

33.27 ± 20.28

129 (65.2%)

1.05 ± 0.33

Present

35.50 ± 21.82

2 (25.0%)

1.00 ± 0.00

P

0.763

0.028*

0.836

Adnexa invasion

Absent

32.55 ± 20.16

111 (62.0%)

1.04 ± 0.34

Present

37.59 ± 20.86

19 (70.4%)

1.08 ± 0.29

P

0.239

0.401

0.691

Wide horizontal

≤2.0

32.07 ± 19.18

95 (61.7%)

1.05 ± 0.37

>2.0

44.49 ± 23.67

35 (67.3%)

1.04 ± 1.92

P

0.003**

0.468

0.840

Lymph node metastasis

Absent

33.77 ± 20.24

127 (64.8%)

1.05 ± 0.33

Present

26.56 ± 21.20

3 (30.0%)

1.00 ± 0.00

P

0.301

0.040*

0.884

  1. **Correlation is significant at the 0.01 level (2-tailed). *Correlation is significant at the 0.05 level (2-tailed).
  2. bThe student t test was applied to compare scores of ki67 and p53 between two groups. Analysis of variance (ANOVA) was applied for comparison of more than 2 groups.
  3. cChi-square analysis was applied for comparison of p53-positive rate between different groups. Fisher exact tests were used if any expected value was less than 5.
  4. dAll p53-negative patients were excluded.
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