Table 3 Influence of conjugates of aminoadamantanes with carbazole derivatives C-1 and C-2 (Fig. 1) on tubulin polymerization.

From: Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment

Compounds

(dA355/dt)max, % (at 100 μM of compound)

No

R

R1

R2

100 ± 14

C-1a

H

H

H

192 ± 14

C-1b

H

H

CH3

249 ± 16

C-1c

Br

Br

H

124 ± 17

C-1d

Br

Br

CH3

104 ± 24

C-1e

CI

CI

H

100 ± 8

C-1f

CI

CI

CH3

101 ± 15

C-2a

H

H

H

155 ± 22

C-2b

H

H

CH3

127 ± 10

C-2c

CH3

H

H

152 ± 12

C-2d

CH3

H

CH3

182 ± 16

C-2e

CH3

CH3

H

158 ± 19

C-2f

CH3

CH3

CH3

133 ± 14

C-2g

F

H

H

164 ± 18

C-2h

F

H

CH3

330 ± 40

Memantine

89 ± 7

Amantadine

98 ± 16

Carbazole

123 ± 12

Paclitaxel (5 μM)

487 ± 32

  1. Data presented as percent of maximum rate of 355 nm absorbance increase due to microtubules assembly. 100% - maximum rate of 355 nm absorbance in control probe with only vehicle (10% of DMSO).
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