Table 1 Characteristics of 28 included studies in the systematic review and meta-analysis.

From: The Prevalence of Depression and Depressive Symptoms among Eye Disease Patients: A Systematic Review and Meta-analysis

Study

Country

Disease

Age, y

Study Design

Diagnostic Method

Outcome

Depression Prevalence (case/participant)

NOS

Kong, X.11

China

Glaucoma

Mean (SD) 55.5 (NR)

Cross-sectional study

SDS

≥50

48% (48/100)

2

Hallak, J. A.13

US

DED

Mean (SD) 52.6 (16.2)

Cross-sectional study

BDI

>9

38% (19/50)

3

Van der Aa, H. P.14

Netherland

Eye disease

Mean (SD) 77.6 (9.3)

Cross-sectional study

CES-D

≥16

5% (33/615)

3

Ayaki, M.10

Japan

Eye disease

Mean (SD) 59.5 (19.9)

Descriptive study

HADS

≥10

45% (332/730)

3

Vehof J.34

British

DED

Mean (SD) 57.1 (13.1)

Cross-sectional study (population-based)

Clinical diagnosis

NR

17% (64/367)

3

Labbé A35

China

DED

Mean (SD) 67.3 (9.6)

Cross-sectional study (population-based)

SDS

≥40

14% (33/241)

3

Eramudugolla, R.15

Australia

Age-related eye disease

Mean (range) NR (>70)

Cross-sectional study (population-based)

GADS

NR

7% (20/287)

1

Agorastos, A.16

Germany

Glaucoma

Mean (range) NR (>50)

Descriptive study

BDI-II

≥10

36% (31/86)

3

Jivraj, J.17

Canada

AMD

Mean (range) NR (>50)

Descriptive study

CES-D

≥16

21% (20/94)

4

Richards, H. S.18

UK

Ptosis

Mean (SD) 61.6 (15.3)

Descriptive study

HADS

>10

11% (6/57)

2

Kim, S.19

Korea

RP

Mean (SD) 40.1 (11.0)

Cross-sectional study (population-based)

NR

NR

35% (65/187)

1

Lee, W. J.20

Korea

AMD

Mean (SD) 55 (NR)

Descriptive study

GDS

≥5

26% (28/107)

3

Zhou, C.21

China

Glaucoma

Mean (SD) 55.4 (15.3)

Descriptive study

HADS

>10

16% (83/506)

3

Qian, Y.8

US

Ocular inflammation

Mean (range) NR (>18)

Descriptive study

BDI

>13

27% (28/104)

2

Popescu, M. L.22

Canada

Eye disease

Mean (range) NR (>65)

Cross-sectional study

GDS-15

≥5

31% (71/227)

4

Yochim, B. P.23

US

Glaucoma

Mean (SD) 70 (9.2)

Descriptive study

GDS

≥5

12% (5/41)

3

Wang, S. Y.24

US

Glaucoma

Mean (SD) 66.9 (1.03)

Cross-sectional study (population-based)

PHQ-9

≥10

11% (49/453)

4

Kim, K. W.12

Korea

DED

Mean (SD) 71. 9 (5.8)

Cross-sectional study (population-based)

SGDS-K

NR

33% (66/198)

1

Amaro, T. A.25

US

Uveal melanoma

Mean (range) 52 (29–80)

Descriptive study

BDI

>11

45% (9/20)

3

Tastan, S.26

Turkey

Glaucoma

Mean (SD) 64.2 (13.2)

Cross-sectional study

HADS

≥8

57% (69/121)

4

Freeman, E. E.27

Canada

Cataract

Mean (range) NR (>45)

Descriptive study

GDS-30

≥10

26% (174/657)

2

Banerjee, A.28

US

AMD

Mean (range) NR (>50)

Descriptive study

GDS

>4

26% (14/53)

3

Mabuchi, F.29

Japan

Glaucoma

Mean (SD) 66.9 (12.1)

Cross-sectional study

HADS

>10

11% (25/230)

3

Skalicky, S.30

Australia

Glaucoma

Mean (range) NR (70–90)

Descriptive study

GDS-15

>4

19% (25/131)

3

Augustin, A.7

France Germany Italy

AMD

Mean (SD) 77 (NR)

Descriptive study

HADS

≥11

18% (60/336)

4

Sun, C.31

Australia

AMD

Mean (range) NR (69–97)

Cross-sectional study

CES-D

≥10

16% (58/367)

3

Cumurcu, T.32

Turkey

Glaucoma

Mean (range) NR (30–80)

Cross-sectional study

HDRS

NR

25% (18/73)

4

Brody, B. L.33

US

AMD

Mean (SD) 80 (NR)

Descriptive study

DSM

DSM-IV criteria

32% (49/151)

1

Total

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25% (1502/6589)

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  1. NR = Not related; Abbreviations: AMD, Age-related Macular Degeneration; DED, Dry Eye Disease; RP, Retinitis Pigmentosa; SDS, Self-Rating Depression Scale; HADS, Hospital Anxiety and Depression Scale; BDI, Beck Depression Inventory; CES-D, Center for Epidemiologic Studies Depression Scale; DSM, Diagnostic and Statistical Manual of Mental Disorders (Forth Edition);HADS, Hospital Anxiety and Depression Scale; NOS, Newcastle-Ottawa Score; NR, not reported; PHQ-9,9-item Patient Health Questionnaire; GDS, Geriatric Depression Scale; SGDS-K, the Korean version of Short Geriatric Depression Scale; SDS, Self-rating Depression Scale; GADS, Goldberg Anxiety and Depression Scale; HDRS, Hamilton Depression Rating Scale.