Table 3 The effect of free rhMBP and rhMBP NPs on clinical scores of EAE in mice 14 days post induction.

From: Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model

Groups

Clinical score

Normal Control

0 ± 0.0

EAE

2.1 ± 0.3*

Free rhMBP treated control

0 ± 0.0

rhMBP NPs treated control

0 ± 0.0

Free rhMBP pretreated EAE

1.4 ± 0.2@

rhMBP NPs pretreated EAE

1.1 ± 0.2@

  1. Statistical analysis was carried out by non-parametric one-way ANOVA followed by Dunn’s multiple comparisons test for comparison of means of different groups.
  2. Each value represents mean ± SE (n = 15 mice).
  3. *Significantly different from normal control group at P < 0.05.
  4. @Significantly different from EAE-control group at P < 0.05.
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