Table 4 The effect of free rhMBP and rhMBP NPs on inflammatory markers in mice brains.

From: Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model

Groups

TNF-α (pg/g wet wt)

IFN-γ (pg/g wet wt)

IL-17 (pg/g wet wt)

IL-10 (pg/g wet wt)

Normal control

13.88 ± 1.20

23.56 ± 1.33

10.44 ± 0.65

53.50 ± 2.15

EAE

84.16 ± 5.31*

115.46 ± 7.20*

55.50 ± 3.01*

14.80 ± 0.92*

Free rhMBP treated control

8.66 ± 0.61@

18.46 ± 0.96@

7.25 ± 0.32@

61.82 ± 2.23@

rhMBP NPs treated control

7.22 ± 0.66@

15.43 ± 0.82@

6.96 ± 0.41@

66.60 ± 3.32@

Free rhMBP pretreated EAE

38.66 ± 2.11@*

53.08 ± 2.23@*

31.32 ± 1.25@*

31.10 ± 2.02@*

rhMBP NPs pretreated EAE

27.48 ± 1.34 #@*

41.20 ± 2.01@*

22.34 ± 1.03@*

41.12 ± 2.11#@

  1. Each value represents mean ± SE (n = 12 mice).
  2. *Significantly different from normal control group at P < 0.05.
  3. @Significantly different from EAE group at P < 0.05.
  4. #Significantly different from free rhMBP pretreated EAE group at P < 0.05.
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