Figure 4: Effects of c-Met inhibitor on wound healing in control and K-Arf6-cKO mice.

(A–D) DMSO or 33 μg of PHA665752 were applied every day after wounding, and wound closure was analyzed up to 8 days. Representative images of the dorsal skin wound healing in control (A) and K-Arf6-cKO mice (C). Quantitative data for control (B) and K-Arf6-cKO (D) mice were shown as means ± SEM from four independent experiments. Statistical significance was assessed using Student’s t-test, *P < 0.05. Scale bar, 5 mm.