Figure 6: Schematic illustration summarizing the main findings in the present study. | Scientific Reports

Figure 6: Schematic illustration summarizing the main findings in the present study.

From: Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy

Figure 6

Fucosylated and mannosylated glycoconjugates on F. hepatica interact with DC-SIGN expressed on the DC surface, triggering a tolerogenic program together with TLR signaling that induces enhanced expression of IL-10 and IL-27 by DCs and differentiates naïve CD4+ T cells into anergic/regulatory T cells.

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