Table 2 Regression analysis for left and right hippocampal volumes as dependent factors and the independent factors GLIZ mRNA, GR mRNA, IL-6, CRP, childhood maltreatment total score and age for patients with MDD and healthy controls

From: Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder

 

Left hippocampus

Right hippocampus

 

Beta

T

P -value

Beta

T

P -value

Patients

 GILZ mRNA

0.59

3.4

0.002

0.57

3.3

0.003

 GR mRNA

−0.05

−0.29

0.77

−0.03

−0.16

0.87

 IL-6

−0.44

−2.1

0.044

−0.44

−2.1

0.046

 CRP

0.42

2.0

0.051

0.38

1.8

0.08

 Childhood maltreatment total score

0.17

0.97

0.34

0.01

0.06

0.95

 Age

0.14

0.81

0.43

0.24

1.3

0.20

Healthy subjects

 GILZ mRNA

−0.13

−0.62

0.54

−0.16

−0.75

0.46

 GR mRNA

0.08

0.34

0.74

0.03

0.15

0.89

 IL-6

0.05

0.30

0.77

−0.16

−0.89

0.38

 CRP

−0.17

1.0

0.32

0.38

1.8

0.08

 CTQ total score

0.07

0.40

0.69

0.02

0.11

0.91

 Age

−0.15

0.80

0.43

−0.21

−1.2

0.25

  1. Abbreviations: CRP, C-reactive protein; CTQ, Childhood Trauma Questionnaire; IL, interleukin; GILZ, glucocorticoid-inducible genes Leucin Zipper; GR, glucocorticoid receptor; MDD, major depressive disorder.
Back to article page