Figure 1 | Translational Psychiatry

Figure 1

From: ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions

Figure 1

Effects of intraventricular infusion of ZD1839 on pulse-alone startle and prepulse inhibition of epidermal growth factor (EGF) rats. (a) ZD1839 (1 mg ml−1; 12 μg per day) or vehicle (10% dimethyl sulfoxide) was administered to the lateral cerebroventricle for 8–10 days. Pulse-alone startle of EGF or control rats with a vehicle or ZD1839 pump was measured with a 120-dB tone as adults. (b) Prepulse inhibition was determined in the presence of 75-, 80- and 85-dB prepulse stimuli. Bars indicate means±s.e.m. (n=10 each). **P<0.01, ***P<0.001, compared with control rats receiving vehicle and ++P<0.01, +++P<0.001, compared with EGF rats receiving vehicle (by Fisher LSD).

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