Figure 5 | Translational Psychiatry

Figure 5

From: ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions

Figure 5

Effects of ZD1839 and conventional antipsychotics on pallidal dopamine metabolism. (a) ZD1839 (12 μg per day, intraventricular), (b) risperidone (1.0 mg per day) or haloperidol (0.3 mg per day) was subchronically administered to epidermal growth factor (EGF) and control rats for 10–13 days. Monoamines were then extracted from the globus pallidus, and tissue concentrations of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured by high-performance liquid chromatography combined with an electrochemical detector. *P<0.05, **P<0.01, ***P<0.001, compared with control rats receiving vehicle and +P<0.05, ++P<0.01, +++P<0.001, compared with EGF rats receiving vehicle by Fisher LSD.

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