Table 1 Inhibition of ErbB1 phosphorylation in vivo

From: ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions

Brain region

Vehicle

PD153035

Prefrontal cortex

0.196±0.017

0.174±0.034

Basal ganglia

0.292±0.025

0.198 ±0.019**

Hippocampus

0.226±0.009

0.142±0.017*

Hypothalamus

0.330±0.039

0.296±0.016

Midbrain

0.274±0.011

0.282±0.031

  1. Brain tissue lysates were prepared from the prefrontal cortex, basal ganglia (that is, striatum+nucleus accumbens+globus pallidus), hippocampus, hypothalamus and midbrain of epidermal growth factor (EGF) rats receiving vehicle (10% dimethyl sulfoxide) or PD153035 (12 μg per day) for 12 days (n=5 rats each). Lysates were subjected to an enzyme immunoassay for phospho-ErbB1 with the cell lysate from an EGF-stimulated A431 cells as a standard. Data are expressed as mean±s.e.m. (arbitrary units). *P<0.05, **P<0.01 by Fisher’s LSD.
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