Figure 2
Schematic overview of metabolite concentration differences in moderate-to-heavy drinkers (MHD) compared with light drinkers (LD) in males and females. Ten/five metabolites that best discriminate MHD from LD in males/females are shown. Yellow and blue boxes represent male- and female-specific alcohol-related metabolites identified in this study. Combined yellow-blue boxes represent metabolites identified both in males and females. Bold black arrows represent observed higher or lower of metabolite concentration in MHD compared with LD in the discovery. Replicated metabolites are marked by a star. Thin black arrows represent the higher or lower of alcohol-related analytes in MHD reported in earlier publications. Red boxes represent alcohol-related enzymes and red arrows represent the effect on the respective enzyme activity or concentration reported in previous publications in MHD. ASM, acid sphingomyelinase; LCAT, lecithin-cholesterol acyltransferase; PAF, platelet-activating factor; PLA2, phospholipase A2; PLD, phospholipase D.
