Table 2 Results of logistic regression analysis of alcohol-specific metabolites in males

	Discovery KORA F4 (n=1144)			Replication KORA F3 (n=154)			Meta analysis discovery+replication fixed effects (n=1298)
Metabolite	LD^amean±s.d. (μ M)^b	MHD^cmean±s.d. (μ M)^b	P-value^d,^e	LD mean±s.d. (μ M) ^b	MHD mean±s.d. (μ M) ^b	P-value^d,^f	LD mean±s.d. (μ M) ^b	MHD mean±s.d. (μ M) ^b	P-value^d,^f
PC aa C32:1	19.3±9.2	31.0±16.9	1.1E−18	20.7±9.7	35.0±16.5	7.3E−05	19.4±9.2	31.6±16.8	8.6E−23
PC aa C36:5	28.7±12.9	36.6±17.6	3.9E−07	31.8±19.8	44.0±278	4.9E−02	29.0±13.9	37.7±19.5	5.6E−08
PC aa C40:4	4.0±1.2	4.9±1.6	1.2E−07	3.7±1.0	4.7±1.5	1.6E−02	4.0±1.2	4.8±1.6	2.8E−09
PC aa C36:1	51.4±11.9	59.7±16.4	6.6E−06	53.0±11.2	66.6±15.9	9.9E−04	51.5±11.8	60.7±16.5	9.9E−09
lysoPC a C17:0	1.7±0.5	1.5±0.5	5.4E−10	1.6±0.4	1.3±0.4	3.4E−02	1.7±0.5	1.5±0.5	4.1E−11
lysoPC a C18:1	20.0±5.5	22.7±7.4	1.6E−05	18.5±4.9	20.9±5.0	1.3E−01	19.9±5.4	22.5±7.1	3.9E−06
PC ae C40:6	4.9±1.2	4.4±1.1	4.3E−10	5.4± 1.3	5.0±1.1	3.5E−02	4.9±1.2	4.5±1.1	1.5E−10
SM(OH) C16:1	3.1±0.7	2.7±0.7	6.8E−12	2.7±0.7	2.4±0.6	2.0E−03	3.0±0.7	2.6±0.7	1.2E−13
SM(OH) C22:1	12.6±2.5	11.4±2.9	3.4E−09	10.0±2.5	9.3±2.1	1.2E−02	12.3±2.6	11.1±2.9	4.4E−10
SM(OH) C22:2	10.2±2.1	9.1±2.3	4.0E−13	8.1±2.1	7.7±1.7	2.3E−02	9.9±2.2	8.9±2.3	1.3E−13

Abbreviations: LD, light drinkers; MHD, moderate-to-heavy drinkers.
^aAlcohol consumption <40 g day⁻¹ males, <20 g day⁻¹ females.
^bMean and s.d. of the metabolite concentration from serum.
^cAlcohol consumption ⩾40 g day⁻¹ males, ⩾20 g day⁻¹ females.
^dLogistic regression analysis adjusted for age, body mass index, smoking, high-density lipoproteins and triglycerides.
^eSignificance level <0.00038 (Bonferroni corrected).
^fSignificance level <0.005 males (Bonferroni corrected). Significant P-values are represented in bold.

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