Table 3 Results from logistic regression analysis of alcohol-specific metabolites in females

	Discovery KORA F4 (n=946)			Replication KORA F3 (n=107)			Meta analysis discovery+replication fixed effect (n=1053)^a			Replication TwinsUK (n=277)
Metabolite	LD^b mean±s.d. (μ M)^c	MHD^d mean±s.d. (μ M)^c	P-value^e,^f	LD mean±s.d. (μ M)^c	MHD mean±s.d. (μ M)^c	P-value^e,^g	LD mean±s.d. (μ M)^c	MHD mean±s.d. (μ M)^c	P-value^e,^g	LD mean±s.d. (μ M)^c	MHD mean±s.d. (μ M)^c	P-value^e,^g
PC aa C34:1	241.1±52.9	259.4±56.3	1.0E−04	274.8±72.8	308.5±73.6	5.8E−02	244.6±56.2	263.7±59.6	6.6E−05	311.5±98.8	350.4±121.0	9.4E−03^h
lysoPC a C16:1	2.8±0.9	3.1±1.0	4.7E−05	2.5±1.0	3.04±0.9	5.2E−02	2.7±0.8	3.1±1.0	6.2E−06	4.21±1.5	4.24±1.7	7.3E−01
lysoPC a C17:0	1.8±0.5	1.6±0.5	2.8E−04	1.6±0.5	1.4±0.4	2.3E−02	1.7± 0.5	1.6±0.4	7.7E−05	2.3± 0.9	2.2±0.7	5.6E−01
PC ae C30:2	0.17±0.04	0.16±0.04	4.0E−05	0.17±0.03	0.15±0.04	2.5E−03	0.16± 0.04	0.15±0.03	4.2E−06	0.2± 0.1	0.2±0.1	7.8E−01
PC ae C40:6	5.4±1.3	5.0±1.2	2.4E−07	6.1±1.5	5.4±1.4	2.2E−02	5.4±1.3	5.0±1.2	1.7E−08	7.5±2.7	7.4±2.7	9.9E−01

Abbreviations: LD, light drinkers; MHD, moderate-to-heavy drinkers.
^aMeta analysis consist of KORA F4 discovery, KORA F3 and TwinsUK replication data sets.
^bAlcohol consumption <40 g day⁻¹ males, <20 g day⁻¹ females.
^cMean and s.d. of the metabolite concentration from serum.
^dAlcohol consumption ⩾40 g day⁻¹ males, ⩾20 g day⁻¹ females.
^eLogistic regression analysis adjusted for age, body mass index, smoking, high-density lipoproteins and triglycerides.
^fSignificance level <0.00038 (Bonferroni corrected).
^gSignificance level <0.01 females (Bonferroni corrected).
^hLogistic regression analysis adjusted for age, BMI, smoking with n=629 study participants. Significant P-values are represented in bold.

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