Figure 2 | Translational Psychiatry

Figure 2

From: Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384

Figure 2

ABT-384 inhibits its target 11-beta-hydroxysteroid dehydrogenase type 1 (HSD-1) in the liver. Spot urine samples were collected before dosing and four times between 2 and 40 h after five daily doses of ABT-384. The HSD-1 ratio is urine cortisol metabolites (5-α-tetrahydrocortisol+5-β-tetrahydrocortisol) divided by urine cortisone metabolite (tetrahydrocortisone). The median of two individuals is represented for each regimen.

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