Figure 2 | Translational Psychiatry

Figure 2

From: N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

Figure 2

NAC affects brain weight but not body weight of R6/1 mice. (a) A significant interaction between genotype and treatment was found in the brain weight of 17-week-old mice. Post hoc analyses revealed that saline-treated HD mice had significantly lower brain weights than WT mice, and NAC partially restored this. (b) A significant age × genotype interaction was found in body weight. Post hoc tests revealed that the genotype difference began at 12 weeks of age and progressively increased until 17 weeks. Error bars represent mean±s.e.m.; n=10–14; treatment effects: ***P<0.001. HD, Huntington’s disease; NAC, N-acetylcysteine; WT, wild type.

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