Figure 3

Western blot analysis of astrocytic glutamate transporter proteins in the striatum and cortex. (a–b) GLT-1 was significantly reduced in the striatum and cortex of HD mice, but was unaffected by NAC treatment. (c–d) Protein levels of xCT were unchanged across genotype and treatment. Error bars represent mean±s.e.m.; n=7–8; genotype effects: #P<0.05. HD, Huntington’s disease; NAC, N-acetylcysteine; WT, wild type.