Table 1 Mann–Whitney U-test, P-values of the difference in levels of acute phase proteins among neonates to exposed and unexposed mothers (median, 25th–75th percentile), controls and cases separately
APP | T. gondii | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Controls | Neonates who will develop non-affective psychosis, ICD-10 F20–29 | Neonates who will develop schizophrenia, ICD-10 F20 | |||||||
Unexposed (n=403) | Exposed (n=122) | P | Unexposed (n=153) | Exposed (n=46) | P | Unexposed (n=30) | Exposed (n=16) | P | |
a-2-Macroglobulin (ng ml−1) | 357 (137–615) | 594 (352–895) | *** | 340 (158–589) | 420 (129–824) | NS | 282 (101–508) | 368 (128–606) | NS |
Haptoglobulin (ng ml−1) | 6.0 (2.6–21.1) | 11.2 (3.3–36.4) | *** | 6.3 (2.5–15.7) | 6.4 (2.3–22.4) | NS | 6.2 (2.1–42.1) | 6.6 (1.6–23.9) | NS |
C-reactive protein (ng ml−1) | 0.6 (0.2–1.8) | 1.1 (0.5–2.4) | ** | 0.6 (0.2–1.3) | 0.8 (0.2–2.2) | NS | 0.5 (0.1–1.3) | 0.3 (0.1–1.2) | NS |
Serum amyloid P (ng ml−1) | 10.3 (5.1–16.1) | 13.8 (7.8–20.5) | *** | 8.8 (4.7–15.2) | 11.0 (6.1–16.0) | NS | 8.6 (4.2–13.3) | 10.0 (5.1–12.5) | NS |
Procalcitonin (pg ml−1) | 2.1 (0.8–3.3) | 3.3 (1.4–5.2) | *** | 1.9 (0.8–3.2) | 2.6 (0.8–4.4) | NS | 2.0 (0.3–2.6) | 2.2 (0.2–4.4) | NS |
Ferritin (pg ml−1) | 1130 (301–2500) | 2350 (665–4760) | *** | 1430 (331–2830) | 1800 (260–4290) | NS | 1080 (220–2580) | 1250 (150–3920) | NS |
tPA (pg ml−1) | 3.6 (1.3–6.0) | 4.8 (2.2–6.9) | * | 3.1 (1.0–5.3) | 2.2 (0.0–5.6) | NS | 2.9 (0.8–4.9) | 2.3 (0.0–4.4) | NS |
Fibrinogen (ng ml−1) | 6.8 (2.2–17.9) | 14.9 (2.7–46.2) | ** | 7.6 (2.6–24.9) | 3.6 (1.2–20.9) | NS | 3.7 (2.7–26.5) | 2.6 (0.4–13.0) | NS |
Serum amyloid A (ng ml−1) | 1.6 (0.7–3.5) | 2.2 (1.0–5.0) | ** | 1.5 (0.7–2.9) | 1.2 (0.4–2.4) | NS | 1.7 (0.7–2.1) | 1.2 (0.0–2.3) | NS |
APP score | 0.1 (−0.7 to –0.6) | 0.6 (−0.8 to –1.1) | *** | 0.2 (−0.6 to –0.5) | 0.1 (−0.6 to –0.8) | NS | 0.1 (−0.8 to –0.5) | −0.2 (−1.1 to –0.4) | NS |
APP | CMV | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Controls | Neonates who will develop non-affective psychosis, ICD-10 F20–29 | Neonates who will develop schizophrenia, ICD-10 F20 | |||||||
Unexposed (n=135) | Exposed (n=390) | P | Unexposed (n=48) | Exposed (n=151) | P | Unexposed (n=8) | Exposed (n=38) | P | |
a-2-Macroglobulin (ng ml−1) | 348 (83.2–588) | 431 (187–698) | ** | 340 (100–565) | 355 (159–678) | NS | 343 (128–521) | 336 (101–551) | NS |
Haptoglobulin (ng ml−1) | 5.1 (2.3–17.5) | 7.2 (2.8–27.8) | * | 5.7 (2.2–22.3) | 6.5 (2.8–16.1) | NS | 1.9 (1.6–37.5) | 7.1 (2.4–37.0) | NS |
C-reactive protein (ng ml−1) | 0.7 (0.2–2.0) | 0.8 (0.2–1.9) | NS | 0.8 (0.2–1.7) | 0.6 (0.2–1.4) | NS | 0.8 (0.1–0.9) | 0.4 (0.1–1.2) | NS |
Serum amyloid P (ng ml−1) | 9.4 (4.3–16.5) | 11.5 (6.1–18.0) | * | 8.9 (5.8–14.3) | 8.9 (4.8–17.0) | NS | 7.9 (6.0–10.8) | 9.0 (4.2–13.3) | NS |
Procalcitonin (pg ml−1) | 1.9 (4.3–16.5) | 2.3 (0.9–3.8) | * | 1.8 (0.8–3.2) | 2.0 (0.8–3.5) | NS | 2.3 (0.4–3.5) | 1.9 (0.3–3.5) | NS |
Ferritin (pg ml−1) | 965 (191–2410) | 1590 (439–3180) | ** | 1230 (259–2720) | 1730 (335–3130) | NS | 960 (250–2080) | 1180 (120–2660) | NS |
tPA (pg ml−1) | 3.0 (0.9–5.8) | 4.1 (2.0–6.4) | * | 2.8 (1.0–4.8) | 3.1 (0.5–5.6) | NS | 2.4 (0.6–5.3) | 2.9 (0.2–4.6) | NS |
Fibrinogen (ng ml−1) | 5.2 (2.0–17.0) | 8.2 (2.4–27.3) | * | 5.3 (2.5–16.0) | 7.4 (2.1–26.2) | NS | 3.5 (3.0–20.0) | 3.4 (1.4–26.1) | NS |
Serum amyloid A (ng ml−1) | 1.4 (0.6–3.0) | 1.8 (0.9–4.1) | * | 1.2 (0.5–3.0) | 1.6 (0.6–2.8) | NS | 0.9 (0.2–2.4) | 1.5 (0.6–2.1) | NS |
APP score | 0.1 (−1.1 to –0.6) | 0.3 (−0.5 to –0.8) | * | 0.1 (−0.5 to –0.6) | 0.1 (−0.6 to –0.6) | NS | −0.3 (−0.6 to –0.5) | 0.1 (−1.0 to –0.4) | NS |
