Table 3 List of the top 20 genes in GC2
From: Genetic association of impulsivity in young adults: a multivariate study
SNP | Gene | Name | CHR | ZS | RW | Function | Associated disease and/or behaviors |
|---|---|---|---|---|---|---|---|
rs1008805 | CYP19A1 a | Cytochrome p450, family 19, subfamily A, polypeptide 1 | 15q21.1 | −5.05 | 1.00 | Regulates aromatase activity in catalyzing estrogen biosynthesis from androgens | Obesity, impulsivity |
rs6467802 | ATP6V0A4 a | ATPase, H+ transporting, lysosomal V0 subunit a4 | 7q34 | −4.82 | 0.95 | Neurotransmitter release | Unknown |
rs6952633 | PDE1C | Phosphodiesterase 1C | 7p14.3 | 4.79 | 0.94 | Neuronal plasticity. Hydrolyzes cAMP and cGMP | Male mating problems in melanogaster |
rs1224391 | PRKG1 a | Refer to Table 4 | — | 4.76 | 0.94 | — | — |
rs8028974 | RYR3 a | Ryanodine receptor 3 | 15q14–q15 | 4.60 | 0.91 | Relases calcium from intracellular storage. Neuronal plasticity. Role in CBF and pathological brain response | Social contact, pain sensitivity, fear conditioning |
rs12777566 | CTNNA3 | Catenin alpha 3 | 10q22.2 | −4.57 | 0.90 | Cell–cell adhesion | AD |
rs9650418 | PPP2R2A | Protein phosphatase 2, regulatory subunit B, alpha | 8p21.2 | 4.53 | 0.89 | Unknown | Height |
rs1313762 | ABCG2 a | ATP-binding cassette, subfamily G, member 2 | 4q22 | 4.52 | 0.89 | Brain development. | AD, drug abuse |
rs8080721 | PRKCA a | Protein kinase C, alpha | 17q22–q23.2 | 4.51 | 0.89 | Emotional memory formation | PTSD, SZ, alcoholism, obesity |
rs1704917 | CHST11 | Refer to Table 4 | — | 4.44 | 0.87 | — | — |
rs924138 | ABCC1 | ATP-binding cassette, subfamily C, member 1 | 16p13.1 | 4.41 | 0.87 | Brain development. Drug transport across CNS | AD, neurodevelopment disorders |
rs918241 | RYR2 | Ryanodine receptor 2 | 1q43 | −4.39 | 0.86 | Role in CBF and pathological responses in brain. Neuronal plasticity | SZ |
rs4416750 | MGAM | Maltase–glucoamylase | 7q34 | −4.38 | 0.86 | Brain maturation | Unknown |
rs751933 | KCNK5 | Potassium channel, subfamily K, member 5 | 6p21 | 4.36 | 0.86 | Cell proliferation, migration, apoptosis. Sensitive to environmental stimuli, for example, pH, glucose | MS |
rs362794 | RELN a | Reelin | 7q22 | −4.32 | 0.85 | Synaptic plasticity, brain development. Functional and behavioral development in juvenile prefrontal circuits | ASD, SZ, BP, MDD, AD, impulsivity |
rs16531 | CACNB1 | Calcium channel, voltage-dependent, beta 1 | 17q21–q22 | 4.23 | 0.83 | Synaptic transmission | Unknown |
rs1709834 | PRKCH | Protein kinase C, Eta | 14q23.1 | −4.21 | 0.83 | NRG1 interactor in neurite formation | SZ, MDD |
rs1460756 | MAPK10 | Mitogen-activated protein kinase 10 | 4q22.1–q23 | 4.21 | 0.83 | Neuronal proliferation, differentiation, migration | Anxiety |
rs16948648 | ITGA3 | Integrin alpha 3 | 17q21.33 | 4.17 | 0.82 | Transmembrane glycoprotein connecting extracellular matrix to cytoskeleton | Neural tube defects, SZ |
rs7811880 | WBSCR17 a | Williams–Beuren syndrome chromosome region 17 | 7q11.23 | 4.13 | 0.81 | Lamellipodium formation, O-glycosylation, macropinocytosis | Williams–Beuren syndrome |
