Table 3 Areas of activation associated with correct recognition effect (RC>New) in the 1-back memory load in TD and ASD children

Within-group recognition effects							Group differences
Time windows		Brain area	Pseudo z-values	MNI coordinates
TD children
375–425	R	MTG	0.75	44	−7	−18
	R	Precentral gyrus	0.66	44	8	27
400–450	R	Hippocampus	0.87	42	−12	−18	TD>ASD
	R	Precentral gyrus	0.57	49	8	27
	R	mPFC	0.54	19	48	2
425–475	R	Hippocampus	0.74	39	−12	−18	TD>ASD
450–500	R	Hippocampus	0.52	44	−12	−18
	R	MCC	0.52	4	−27	42	TD>ASD
	R	OFG	0.62	9	28	−23
	L	ACC	0.73	−1	38	22	TD>ASD
475–525	R	ACC	0.72	4	38	7
525–575	R	OFG	0.47	24	23	−18
ASD children
200–250	L	dlPFC	0.52	−26	18	37	ASD>TD
225–275	L	dlPFC	0.64	−21	23	37	ASD>TD
400–450	R	mPFC	0.89	29	53	7
425–475	L	Insula	0.84	−31	−22	22	ASD>TD
	R	Insula	0.83	34	18	7	ASD>TD
450–500	R	Insula	0.73	39	−2	12	ASD>TD
	R	Hippocampus	0.73	29	−17	−13
	R	mPFC	0.78	29	53	7
500–550	L	OFG	0.61	−31	43	−3
	L	ACC	0.61	−1	43	22
525–575	R	MCC	0.66	14	−27	47

Abbreviations: ACC, anterior cingulate cortex; ASD, autism spectrum disorder; dlPFC, dorso-lateral prefrontal cortex; L, left; MCC, middle cingulated cortex; MNI, Montreal Neurological Institute; mPFC, medial prefrontal cortex; MTG, medial temporal gyrus; OFG, orbito-frontal gyrus; PCG, precentral gyrus; R, right; RC, repeat–correct’ trial; TD, typically developing.
Note: Statistical significance was set for the significant voxels of activation at P<0.05, corrected for multiple comparisons in the whole source–space volume for within-group comparisons (recognition effect in each group; RC vs New stimuli) and at P<0.005 uncorrected for between-group comparisons (recognition contrast (RC–New stimuli) by group, highlighted in bold).

Quick links

Search