Table 1 Sample characteristics

From: RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response

 

N

All (N=12)

Non-responder (N=12)

Remitter (N=12)

Value

df

Pa

  

N/mean

(%/s.d.)

N/mean

(%/s.d.)

N/mean

(%/s.d.)

   

Baseline and disease characteristics

 Age, mean (s.d.)

24

44.9

13.5

45.5

15.2

44.3

12.3

0.21

22

0.8382

 Duration of hospital stay (weeks), mean (s.d.)

24

12.1

6.1

16.6

5.4

7.6

2.0

5.32

22

0.0000

 Number of previous episodes, mean (s.d.)

21

4.4

7.4

7.0

9.6

1.6

1.6

1.75

19

0.0964

 Age at disease onset, mean (s.d.)

24

29.8

15.2

28.3

17.0

31.3

13.7

−0.48

22

0.6389

 HAMD at admission, mean (s.d.)

24

28.8

6.1

28.3

5.6

29.3

6.7

−0.36

22

0.7206

 HAMD at discharge, mean (s.d.)

23

6.5

5.4

9.3

5.8

3.5

2.8

2.96

21

0.0074

 HAMD at week 5, mean (s.d.)

22

12.5

8.0

18.9

4.3

4.8

2.2

9.43

20

0.0000

 BMI at admission, mean (s.d.)

23

25.7

4.6

26.7

5.6

24.8

3.4

0.97

21

0.3441

 HAMA at admission, mean (s.d.)

24

26.7

9.5

27.5

9.1

25.8

10.2

0.42

22

0.6775

 Psychotic depression, No. (%)

24

3

12.5

1

8.3

2

16.7

0.38

1

>0.999

 Treatment resistance, No. (%)

24

2

8.3

2

16.7

0

0.0

2.18

1

0.4780

Antidepressants (within 5 weeks), no. of patients (%)

 Tricyclics

24

8

33.3

5

41.8

3

25.0

0.75

1

0.6670

 SSRI

24

7

29.2

3

25.0

4

33.3

0.20

1

>0.999

 SNRI

24

10

41.7

7

58.3

3

25.0

2.74

1

0.2140

 NaSSA (=Mirtazapine)

24

9

37.5

4

33.3

5

41.7

0.18

1

>0.999

 NARI

24

0

 

0

 

0

    

 MAOI

24

1

4.2

0

0.0

1

8.3

1.04

1

>0.999

Others

 Bupropion

24

4

16.7

4

33.3

0

0.0

4.80

1

0.0930

 Trazodon

24

3

12.5

3

25.0

0

0.0

3.43

1

0.2170

 Buspiron

24

1

4.2

1

8.3

0

0.0

1.04

1

>0.999

Psychotropics, others (within 5 weeks), no. of patients (%)

 Antipsychotics

24

15

62.5

9

75.0

6

50.0

1.60

1

0.4000

 Mood stabilizers

24

14

58.3

6

50.0

8

66.7

0.69

1

0.4080

 Lithium

24

3

12.5

2

16.7

1

8.3

0.38

1

>0.999

 Benzodiazepines

24

13

54.2

7

58.3

6

50.0

0.17

1

0.6820

Internal medication (within 5 weeks), no. of patients (%)

 Thyroid medication

24

4

16.7

3

25.0

1

8.3

1.20

1

0.5900

 Analgetics

24

6

25.0

2

16.7

4

33.3

0.89

1

0.6400

 Cardiovascular medication

24

8

33.3

6

50.0

2

16.7

3.00

1

0.1930

 Antibiotics

24

1

4.2

0

0.0

1

8.3

1.04

1

>0.999

  1. Abbreviations: BMI, body mass index; HAMA, Hamilton Anxiety Rating Scale; HAMD, Hamilton Depression Rating Scale.
  2. For some variables, there are missing data and N does not equal number of total patients. Percentages are based on available data. Bold values signify P<0.05.
  3. aTwo-sided t-test and Chi-square, respectively, comparing nonresponders and remitters; Fisher's exact test used when cell count was <5.
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