Table 3 Hippocampal transcript levels in WLIs and WMIs in response to CRS

From: Nature and nurture: environmental influences on a genetic rat model of depression

Gene

WLI ΔCt±s.e.m.

WMI ΔCt±s.e.m.

 

Control

CRS

Control

CRS

Adcy3

7.54±0.11

7.32±0.07

7.29±0.05

7.47±0.11

Amfr

5.37±0.12

4.71±0.16++

6.00±0.41

4.78±0.26**

Atp11c

6.82±0.11

7.51± 0.09*

6.98±0.10

8.40±0.27**

Cadm1

3.93±0.04

3.98±0.11

4.32±0.11

3.69±0.15**

Cd59

5.90±0.40

5.55±0.25

8.02±0.32

8.53±0.43

Cdr2

6.95±0.29

7.75±0.33

8.64±0.32

8.08± 0.36

Cmas

5.78±0.10

5.39±0.16*

5.93±0.08

6.02±0.11

Dgka

11.21±0.12

11.33±0.25

11.66±0.23

11.73±0.17

Fam46a

12.87±0.44

14.06±0.29

12.68±0.28

13.68±0.34+

Irf3

4.26±0.11

5.05±0.45

5.45±0.45

7.04±0.38*

Kiaa1539

7.99±0.03

7.61±0.15+

8.19±0.08

7.66±0.34

Marcks

5.31±0.09

6.02±0.19*

5.85±0.09

4.95±0.27**

Psme1

6.05±0.10

5.78±0.11

6.20± 0.08

6.31±0.20

Raph1

7.50±0.17

6.61±0.14*

9.37±0.19

8.65±0.38*

Tlr7

9.97±0.17

10.15±0.47

10.34±0.41

10.39±0.43

  1. Abbreviations: CRS, chronic restraint stress; WLI, Wistar Kyoto Less Immobile; WMI, Wistar Kyoto More Immobile.
  2. Please note that the ΔCt values relate to relative concentration by 2−ΔCT.
  3. *P<0.05, **P<0.01 by Bonferroni post hoc after significant two-way analysis of variance (strain × environment). Comparisons are within strain and between control and CRS.
  4. +P<0.05, ++P<0.01 by Student’s t-test. Comparisons are within strain and between control and CRS.
Back to article page