Table 2 De novo mutation rate comparisons between our OCD cohort and samples of affected and unaffected individuals evaluated in previous exome-sequencing studies

From: Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways

Study

Observed rate

Poisson, P

95% Confidence interval

Phenotype

Sanders et al.10

1.31 × 10−8

0.02

1.1–3.1

Unaffected sibling of autism proband

Sanders et al.10

1.58 × 10−8

0.89

0.93–2.57

Sporadic autism

Iossifov et al.48

2.00 × 10−8

0.40

0.75–1.99

Sporadic autism

O’Roak et al.12

2.17 × 10−8

0.60

0.68–1.84

Sporadic autism

Rauch et al.7

1.86 × 10−8

0.29

0.78–2.23

Intellectual disability

Girard et al.9

2.59 × 10−8

1

0.47–2.05

Schizophrenia

Xu et al.8

1.73 × 10−8

0.17

0.85–2.34

Schizophrenia

Fromer et al.46

1.61 × 10−8

0.09

0.93–2.46

Schizophrenia

  1. Abbreviation: OCD, obsessive-compulsive disorder.
  2. Observed rates are de novo variants observed per base pair per generation in the sequenced exome; statistical comparison is between the observed rate and our OCD cohort rate of 2.51 × 10-8 using a two-tailed exact rate ratio test of two Poisson counts; 95% confidence interval is the observed rate/OCD cohort rate.
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