Figure 1

Housing paradigms. Exemplary picture of standard housing (SH), enriched environment (EE) and activity wheel (AW) cages used for the experiments, and schematic drawing of the experimental design. One-month-old Tg4-42^het mice were exposed to SH or EE conditions for 11 months. At 12 months mice underwent a battery of behavioral tests followed by body weight assessment, killing and tissue collection. Two-month-old Tg4-42^hom mice were subjected to either SH, EE or AW conditions (with blocked and free wheels) for 3.5 months, followed by behavioral testing and tissue collection.