Figure 1 | Translational Psychiatry

Figure 1

From: Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra syndrome and autism

Figure 1

Neurons differentiated from human induced pluripotent stem cell (hiPSC)-derived neuronal precursor cells (NPCs). Representative images of CTL1, CTL2 and KS-ASD cells expressing the neuronal markers class III beta-tubulin (TUJ), Neurofilament 200 (NF200), and microtubule-associated proteins TAU and MAP2 on day 35 of terminal differentiation. The neurons are also positive for the glutamatergic subtype-specific marker vesicular neurotransmitter transporter 1/2 (vGLUT1/2). Insets highlight the magnified regions of cells immunolabeled for vGlut1/2. Nuclei are counterstained with DAPI. Scale bars=50 μm. KS-ASD, Autism spectrum disorder patient with Kleefstra syndrome.

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