Figure 2 | Translational Psychiatry

Figure 2

From: Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations

Figure 2

TauDN/DN mice do not produce δTau. (a) Brain homogenates from 3 week-old TauDN/DN and wild-type (WT) littermate mice were treated with (+) or without (−) Caspase-3 prior to western blot analysis with the anti-δTau antibody C3. WT, but not TauDN/DN, brain lysates show presence of δTau after Caspase-3 digestion. The (?) indicates a band produced by Caspase-3 in WT sample and reactive with C3 of uncertain nature. (b) ELISA with C3 shows that δTau is present in WT but not TauDN/DN brain lysates (F(2, 20)=126; P<0.0001). Rec. Tau was used as an internal control. All data represent means±s.e.m. (****P<0.0001).

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