Figure 2
From: The P2 promoter of the IGF1 gene is a major epigenetic locus for GH responsiveness
(a) CG-137 methylation correlates negatively with the increment in serum IGF1 after the first GH injection (N=40; R=−0.7, P=3.4 × 10−7); (b) CG-137 methylation correlates negatively with the increment in P2-driven IGF1 transcripts in PBMC in response to acute GH injection in 40 children (R=−0.82, P=5 × 10−11).
