Table 3 Hypothetical tests with 10% of patients in the HR group for different sensitivity values, showing agranulocytosis risks the LR group (1-NPV), in the HR group (PPV) and specificity of the test

From: Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis

Sensitivity

P(A|LR) (1-NPV)

P(A|HR) (PPV)

Specificity

0.200

0.0071

0.016

0.901

0.400

0.0053

0.032

0.902

0.600

0.0036

0.048

0.904

0.800

0.0018

0.064

0.906

1

0

0.080

0.907

  1. Abbreviations: HR, high risk; LR, low risk; NPV, negative predictive value; PPV, positive predictive value.
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