Table 4 Four hypothetical pharmacogenetic tests for clozapine-induced agranulocytosis and their clinical impact

From: Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis

Test

Sensitivity

Size of HR group

P(A|LR) (1-NPV)

P(A|HR) (PPV)

Specificity

Clinical impact

A

0.500

0.004

0.004

1

1

No change in monitoring, but withhold clozapine from HR group

B

0.600

0.200

0.004

0.024

0.803

No change in monitoring

C

0.850

0.100

0.0013

0.068

0.906

Stop monitoring in LR group

D

0.950

0.500

0.0008

0.015

0.504

Stop monitoring in LR group

  1. Abbreviations: HR, high risk; LR, low risk; NPV, negative predictive value; PPV, positive predictive value.
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