Table 5 Characteristics of pharmacogenetic tests that predict adverse drug reactions

From: Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis

Drug

Gene

Test

Performance characteristics

Reference

Abacavir

HLA-B*5701

The HLA-B*5701 allele is associated with hypersensitivity reaction. Carriers should avoid abacavir.

Sensitivity: 100%

Specificity: 96.9%

PPV: 47.9%

NPV: 100%

37

Carbamazepine

HLA-B*1502

The HLA-B*1502 allele is associated with SJS-TEN in Han Chinese. Carriers should avoid carbamazepine.

Sensitivity: 98.3%

Specificity: 97%

PPV: 7.7%

NPV: 100%

38

Purine analogues

TPMT

Impute 2 SNPs to identify patients with zero wildtype alleles, as they are at high risk of myelotoxicity.

Sensitivity: 100%

Specificity: 99.0%

PPV: 80.6%

NPV: 100%

39

  1. Abbreviations: HLA, human leukocyte antigen; NPV, negative predictive value; PPV, positive predictive value; SNP, single nucleotide polymorphism.
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