Research Highlights in 2025

Branched-chain fatty acids fire up the peroxisome

• Martina Wallace
• Ramya S. Kuna
• Christian M. Metallo

ZBP1 links infections to cancer immunotherapy

• Lorenzo Galluzzi
• Spencer Brackett
• Neil Johnson

Myeloperoxidase: one enzyme, two jobs

• Sara Marchese
• Andrea Mattevi

KCNQ1 and PIP₂: it takes two to tango

• Alicia De La Cruz
• H. Peter Larsson

Intestinal GAPs: neuro–epithelial–immune modules for liver protection

• Manuel O. Jakob
• Andreas Diefenbach

LGP2 stops MDA5 translocation to start antiviral signaling

• Jiyoung Jang
• Myung Hyun Jo

Self-RNA Rmrp pre-dimerizes TLR3 for immune activation

• Ailin Han
• Richard A. Flavell

Targeting NNMT in fibroblasts reawakens T cells and restores antitumor immunity

• Moumita Sarkar
• Yi Jiang
• Raghu Kalluri

Deconstructing the architecture of memory engrams

• Yi Zhong
• Bo Lei

White matter interactome in vascular dementia

• Stefan Wendt
• Brian A. MacVicar

An anti-inflammatory autophagic target in chronic diseases

• Prithvi Reddy Akepati
• Vojo Deretic

APOL proteins tune gut immunity via commensal lipid recognition

• Shohei Asami
• Hiroshi Ohno

Osteocalcin has many tricks to get γ-carboxylated

• Mathieu Ferron

Novel organoid culture condition: modeling fetal-like plasticity in colorectal cancer

• Chao Wu
• Min Jung Kim
• J. Joshua Smith

Sabotaging TCR signaling—LAG3 interferes with the CD3ε–LCK interaction

• Gina J. Fiala
• Wolfgang W. Schamel

SIX of one and half-a-dozen USP2 regulating inflammation

• Lin Liu
• John Silke

Broad-spectrum plant immunity: engineering pathogen protease-activated autoactive NLRs

• Qibin Wu
• Wanying Zhao
• Youxiong Que

Cultured human stem cells undergoing gastrulation

• Fan Zhang
• Fan Guo

Centromeres as minefields: host–virus warfare

• Chin Wei Brian Leung
• Fumiko Esashi

Neutrophil maturation holds the secret to human tumor suppression

• Bianca Calí
• Andrea Alimonti