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Volume 28 Issue 12, December 2021

Cover Credit:Suprachoroidal injection provides a new, noninvasive route of delivery for ocular gene therapy. Two weeks after suprachoroidal injection of 7.8x109 genome copies of AAV2tYF-GRK1-GFP in Brown Norway rats, an ocular section shows strong GFP fluorescence (green) and immunostaining for GFP (red) in photoreceptor cell bodies (outer nuclear layer, ONL), inner segments (IS) and outer segments (OS). GRK1 is the photoreceptor-specific rhodopsin kinase promoter.

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