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Acceleration in discovery of rare genetic variants possibly linked with disease may mean an increased risk of false-positive reports of causality; this Perspective proposes guidelines to distinguish disease-causing sequence variants from the many potentially functional variants in a human genome, and to assess confidence in their pathogenicity, and highlights priority areas for development.
Developments in quantum cryptography show that it is possible to protect secrets — from those with superior technology, those who profess to provide our security and even those who manipulate us without our knowledge — under surprisingly weak assumptions.
