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The peptide-centric local stability assay (PELSA) can be used to determine ligand-binding targets and binding regions on a proteome-wide scale with high sensitivity.
ProHap is a Python-based tool that constructs protein sequence databases from phased genotypes of reference panels to enable researchers to account for haplotype diversity in proteomic searches.
In a technological tour de force, a whole-body 11.7-T MRI scanner has been developed. Here images of the human brain are presented while safety for the imaged human volunteers has been ascertained.
Vitessce is a robust and versatile web-based framework for interactive visualization of large-scale multiomics and spatial data at the single-cell level.
Point spread function (PSF) splitting with the ‘Circulator’, which encodes the fluorophore emission band into the PSF, improves the information content of fluorescence microscopy and enables improved super-resolution imaging and single-particle tracking.
The authors present a workflow integrating imaging mass cytometry and imaging mass spectrometry to deconvolute metabolic heterogeneity at the single-cell level.
Smart parallel automated cryo-electron tomography (SPACEtomo) uses deep learning to fully automate data collection from lamella detection to tilt series acquisition, driving the future of cryo-ET through improved throughput and statistics.
The MHz repetition rates available at second-generation X-ray free-electron lasers enable the collection of microsecond time-resolved X-ray scattering data with exceptionally low noise, providing insights into protein structural dynamics.
Scalable tools are needed for the analysis of increasingly large mass spectrometry-based proteomics datasets. quantms offers an open-source, cloud-based pipeline for massively parallel proteomics data analysis.
Photoconversion of popular organic dyes results in blue-shifted emission and altered fluorescence lifetimes that can cause artifacts in quantitative microscopy. These can be avoided through proper labeling strategies such as using exchangeable dyes.
By effective and efficient integration of PacBio HiFi, Oxford Nanopore Technologies ultra-long and other sequencing data types, hifiasm (UL) enables telomere-to-telomere diploid and polyploid genome assembly at a population scale.
brainlife.io is a one-stop cloud platform for data management, visualization and analysis in human neuroscience. It is web-based and provides access to a variety of tools in a reproducible and reliable manner.
SpatialData is a user-friendly computational framework for exploring, analyzing, annotating, aligning and storing spatial omics data that can seamlessly handle large multimodal datasets.
