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  • A new method for genome-wide characterization of the 5′ and 3′ ends of transcripts promises to improve gene discovery and annotation.

    • Brock A Peters
    • Victor E Velculescu
    News & Views
  • An imaging method termed LAMP, based on a newly described photo-activatable fluorophore, promises to illuminate how gap junctions mediate intercellular coupling.

    • David C Spray
    News & Views
  • A remarkably suitable fluorescent tag incorporated into lipids through some clever chemistry produces fluorescent lipids that are excellent mimics of their native counterparts.

    • Gerrit van Meer
    • Rob M J Liskamp
    News & Views
  • Intein-dependent, ultrasensitive, amplified detection of... anything

    • Garry P Nolan
    News & Views
  • Beyond protein destruction: a new real-time assay to measure dynamic changes in ubiquitination promises to highlight the many other roles of this critical protein modification.

    • Sudha K Shenoy
    • Robert J Lefkowitz
    News & Views
  • With the sequencing of the human genome, millions of single-nucleotide polymorphisms, or SNPs, have been discovered and can be used as markers to identify genes contributing to common human diseases. Two large sets of SNPs have now been organized in panels for high-throughput genotyping.

    • Karl W Broman
    • Eleanor Feingold
    News & Views
  • Microarrays have revolutionized gene expression studies and are set to do the same for genome-wide RNA interference screens.

    • Ben Lehner
    • Andrew G Fraser
    News & Views
  • Rapid and accurate identification of protein phosphorylation sites is achieved by a peptide library screen combining the advantages of chemistry in solution and analysis on solid support.

    • Michael B Yaffe
    News & Views
  • A new scanning approach to data acquisition in tandem mass spectrometry promises to increase sensitivity and accuracy of proteomic analysis.

    • Daniel C Liebler
    News & Views

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