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Functions of histone lysine demethylases in a range of developmental and physiological processes are rapidly being uncovered, as are the roles of these enzymes in disease. Histone demethylases also provide a promising new route towards the therapeutic targeting of epigenetic regulators.
Type 2 diabetes has been described as a geneticist's nightmare. Following a recent spate of impressive results from genome-wide association studies, the author looks at how they have advanced our understanding of this disease and informed future use of this approach towards identifying genetic variants in general.
