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In this Perspective article, Huwyler, Binz and colleagues discuss the future of long-term normothermic machine perfusion for livers and propose a staged assessment approach for ex situ perfused organs.
This Perspective discusses the use and potential of large language models and clinical decision support systems in gastroenterology and hepatology, highlighting opportunities, challenges and limitations of large language models and clinical decision support systems in clinical practice. Key directions for research and insights into clinical integration and safe use are also discussed.
Artificial intelligence (AI) is a powerful tool that could be applied to microbiome research. This Perspective discusses best practices and current limitations with the application of AI in microbiome data research, giving insights into future use and practical advice and recommendations on its use.
The global burden of inflammatory bowel disease (IBD) is shifting as countries transition through four epidemiologic stages. This Perspective explores the global evolution of IBD over the next 20 years and proposes strategies for prevention and health-care innovation.
This Perspective article provides a detailed overview of the oesophagus as an immune organ, highlighting its innate immune components and sensing mechanisms that maintain homeostasis and barrier integrity while responding to antigenic and biophysical challenges.
There is clear evidence that public health measures to reduce alcohol consumption are effective, which can have a positive effect on alcohol-related liver disease. In this Perspective, Parker and colleagues discuss public health policies that affect alcohol consumption and alcohol-related liver disease.
This Perspective highlights emerging evidence of an interaction between Clostridiodes difficile and the enteric nervous system (ENS) during infection, discussing underlying mechanisms and how the ENS and extrinsic innervation are affected by C. difficile infection and toxins and how ENS responses contribute to pathogenesis and disease outcomes.
This Perspective discusses misconceptions and controversies in the clinical management of irritable bowel syndrome (IBS), including diagnosis, testing and treatment, among others. Areas in which issues have been resolved and those that require further research and clarification are highlighted.
