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Recent studies have identified a new population of interleukin-22-producing cells in mucosal tissues that share features with both lymphoid-tissue inducer cells and natural killer cells. How are these three cell populations related and what might be the function of the new cell population?
Regulatory T (TReg) cells are crucial for immune homeostasis, and manipulation of their suppressive functions is a possible avenue for immunotherapy. Here, the authors discuss recent advances in our understanding of how the expression of forkhead box P3 (FOXP3), a TReg-cell-specifying transcription factor, is controlled at the molecular level.
Basophils, often regarded as a lesser relative to the mast cell, are now proving to have important, non-redundant roles in immune responses. This Progress article updates us on the latest studies that identify new roles for basophils in allergic reactions and immune regulation.
