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The role of T cell help to B cells was discovered only a few years after the discovery of B cells. In this Timeline article, the author describes the key events that led to the identification of T follicular helper (TFH) cells as the main T helper cell type for B cells.
As we celebrate 50 years since his seminal Nature paper describing separate lineages for B cells and T cells in the chicken, Max Cooper looks back at the early discoveries that made this breakthrough possible and describes how the B cell field emerged.
