Multistable systems, ideally, could stabilize at any desired, switchable state within a continuous spectrum, however, conventional systems are limited to a finite set of discrete steady states. Here, the authors propose a rational framework for achieving continuously tunable multistability through reversible displacement reaction-mediated competition between positive autoregulatory DNA polymerization/nicking modules.
- Rui Zhong
- Yanjie Fu
- Weihong Tan
