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Advanced filters: Author: Álvaro de la Gándara Clear advanced filters

Molecular basis for transposase activation by a dedicated AAA+ ATPase

Solution and cryogenic electron microscopy studies using IS21 as a model transposase system show how AAA+ ATPases induce structural changes to prime target DNA and activate their associated transposases.

Álvaro de la Gándara
Mercedes Spínola-Amilibia
Ernesto Arias-Palomo
ResearchOpen Access26 Jun 2024
Nature

Volume: 630, P: 1003-1011
IS21 family transposase cleaved donor complex traps two right-handed superhelical crossings

Spínola-Amilibia et al. present the cryo-EM structure of the IS21 transposase in complex with the donor DNA and show that IstA recognizes the transposon ends with a highly intertwined configuration to facilitate the strand-transfer reaction.

Mercedes Spínola-Amilibia
Lidia Araújo-Bazán
Ernesto Arias-Palomo
ResearchOpen Access22 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Prevalence and characterization of breakthrough pain in patients with cancer in Spain: the CARPE-DIO study

Concepción Pérez-Hernández
Ana Blasco
Carmen Montoto
ResearchOpen Access27 Nov 2019
Scientific Reports

Volume: 9, P: 1-10