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Showing 1–3 of 3 results
Advanced filters: Author: Élie Besserer-Offroy Clear advanced filters

  • Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective antagonist MK-D-046 and provide insights into hBLT1 ligand recognition and its mechanism of action.

    • Nairie Michaelian
    • Anastasiia Sadybekov
    • Vadim Cherezov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists, which shed light on CysLTR ligand selectivity.

    • Anastasiia Gusach
    • Aleksandra Luginina
    • Vadim Cherezov
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9