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Inceptor counteracts insulin signalling in β-cells to control glycaemia

The insulin inhibitory receptor (inceptor) is identified as a negative regulator of insulin and IGF1 signalling that could be targeted for β-cell regeneration in treatments for diabetes.

Ansarullah
Chirag Jain
Heiko Lickert
Research27 Jan 2021
Nature

Volume: 590, P: 326-331
Generation of pancreatic β cells from CD177⁺ anterior definitive endoderm

Markers that distinguish pancreatic and hepatic progenitors improve stem-cell differentiation to pancreatic β cells.

Pallavi U. Mahaddalkar
Katharina Scheibner
Heiko Lickert
Research27 Apr 2020
Nature Biotechnology

Volume: 38, P: 1061-1072
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation

Katharina Scheibner
Silvia Schirge
Heiko Lickert
Amendments and Corrections22 Jul 2021
Nature Cell Biology

Volume: 23, P: 925
Machine learning based intrusion detection framework for detecting security attacks in internet of things

V. Kantharaju
H. Suresh
Amerah Alabrah
ResearchOpen Access04 Dec 2024
Scientific Reports

Volume: 14, P: 1-10
Inceptor binds to and directs insulin towards lysosomal degradation in β cells

The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

Johanna Siehler
Sara Bilekova
Heiko Lickert
ResearchOpen Access25 Nov 2024
Nature Metabolism

Volume: 6, P: 2374-2390
Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia

Ansarullah
Chirag Jain
Heiko Lickert
Amendments and Corrections12 Mar 2021
Nature

Volume: 592, P: E1
A consensus guide to preclinical indirect calorimetry experiments

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Alexander S. Banks
David B. Allison
Juleen R. Zierath
Reviews24 Sept 2025
Nature Metabolism

Volume: 7, P: 1765-1780
Epithelial cell plasticity drives endoderm formation during gastrulation

Scheibner et al. demonstrate that, during gastrulation in the mouse, epithelial epiblast progenitors upregulate Foxa2 and form the definitive endoderm independently of a full EMT–MET cycle.

Katharina Scheibner
Silvia Schirge
Heiko Lickert
ResearchOpen Access24 Jun 2021
Nature Cell Biology

Volume: 23, P: 692-703
Improved aquila optimizer for swarm-based solutions to complex engineering problems

Himanshu Sharma
Krishan Arora
Hussain AlSalman
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-34
Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

In male mice with diet-induced obesity, deletion of insulin inhibitory receptor (inceptor) in the whole body, in the brain and in pancreatic β cells improves glucose homeostasis, underlining a role of inceptor in regulating glucose homeostasis in the brain and pancreas.

Gerald Grandl
Gustav Collden
Timo D. Müller
ResearchOpen Access28 Feb 2024
Nature Metabolism

Volume: 6, P: 448-457
Targeting pancreatic β cells for diabetes treatment

This Review summarizes emerging concepts for diabetes therapy aimed at specifically altering β cell biology and function, such as β cell insulin signalling, proliferation, differentiation, apoptosis, as well as the selective killing of senescent β cells.

Chirag Jain
Ansarullah
Heiko Lickert
Reviews21 Sept 2022
Nature Metabolism

Volume: 4, P: 1097-1108

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