Oligodendrocyte progenitor cells (OPCs) contribute to developmental synapse elimination in animal models. Here, the authors use a human brain organoid model to demonstrate that that uptake of synapses in a subset of human OPCs depends on growth arrest-specific gene 6 (GAS6)-AXL signaling.
- Asimenia Gkogka
- Susmita Malwade
- Carl M. Sellgren
