Gastrointestinal endoscopy has a central role in the evaluation and management of gastrointestinal diseases. This procedure during pregnancy, however, raises the unique issue of fetal safety. This Review addresses the need for cohesive information on endoscopic safety in pregnancy by comprehensively reviewing the subject and synthesizing practical clinical recommendations. The article aims to enable clinicians to make decisions on performing endoscopy, employ procedural modifications to enhance fetal safety, and to advise their pregnant patients about fetal risks.