In this article, Kuipers and colleagues review how bile acids modulate glucose and lipid metabolism. The authors discuss the mechanisms by which bile acids, agonists of bile acid signalling pathways and bile acid sequestrants influence glucose levels in animal models and patients with insulin resistance and type 2 diabetes mellitus and how altered bile acid metabolism might contribute to the beneficial effects of bariatric surgery.
- Folkert Kuipers
- Vincent W. Bloks
- Albert K. Groen
