The tyrosine kinase receptor ErbB2 has been implicated in cancer, particularly breast cancer. It has been suggested that its oncogenic signalling properties result from the absence of a key 'tether' in the extracellular region that autoinhibits other human ErbB receptors. ErbB2 is now shown to be the closest structural relative of the dEGFR receptor in Drosophila; although dEGFR also lacks a tether, a distinct set of autoinhibitory interactions keep it inactive.
- Diego Alvarado
- Daryl E. Klein
- Mark A. Lemmon
