Elevated levels of Dickkopf-1 (DKK1), a soluble inhibitor of the Wnt/β-catenin pathway, are associated with poor prognosis in patients with breast cancer. Here the authors show that bone- and cancer-associated fibroblast-derived DKK1 contribute to breast cancer progression by suppressing NK cell cytotoxicity
- Seunghyun Lee
- Biancamaria Ricci
- Roberta Faccio